Module Explorer

Instructions


  • Enter a module name.
  • Click Submit to search for the detailed information of the module.
  • Results will appear below if available.

Selected Module: B_10_10


Module Info

Module_Name B_10_10
Cell_Type B
Name B_10_10: HALLMARK_TNFA_SIGNALING_VIA_NFKB
Meta_Module B_12
Gene_Number 41

Genes:

ALG13, AREG, BTG2, CCNL1, CD69, CD83, CHMP1B, COQ7, CSRNP1, CXCR4, DDIT3, DUSP1, DUSP2, EIF1, FOS, FOSB, GADD45B, IER2, IFRD1, JUN, JUNB, JUND, KLF6, LY9, MYADM, NFKBIA, NFKBID, NR4A1, NR4A2, PHACTR1, PMAIP1, PPP1R15A, RBM38, SBDS, SERTAD1, SLC2A3, TSC22D3, TUBA1A, YPEL5, ZFP36, ZNF331


UMAP Visualizations


UMAP for B_10_10

UMAP for B_10_10


Word Cloud

Enriched TF

Wordcloud for B_10_10
TF p.adjust Genes
PSMB5 4.90379990902434e-09 BTG2/CCNL1/DUSP1/EIF1/JUNB/PMAIP1/PPP1R15A/SLC2A3/TUBA1A/ZFP36
CREB 4.90379990902434e-09 AREG/CHMP1B/DUSP1/EIF1/FOSB/JUND/NR4A2/PPP1R15A/TSC22D3
CREB 4.90379990902434e-09 AREG/DUSP1/FOSB/JUN/JUND/NFKBID/NR4A2/PPP1R15A/TSC22D3
CREB 1.73096420202783e-08 DUSP1/EIF1/FOS/FOSB/GADD45B/NFKBID/NR4A2/PPP1R15A/TSC22D3
SRF 1.17134429958281e-07 DUSP2/FOS/FOSB/IER2/IFRD1/JUNB/KLF6/NR4A1
CREB 3.64129821560901e-07 DUSP1/EIF1/FOS/FOSB/NFKBID/NR4A2/PPP1R15A/TSC22D3
ATF 6.82227196758743e-07 AREG/CHMP1B/DUSP1/FOS/FOSB/JUND/PPP1R15A
SRF 1.34911861648055e-06 DUSP2/FOS/FOSB/IER2/JUNB/KLF6/NR4A1


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
WikiPathways B_10_10 WP1528 Physiological and pathological hypertrophy of the heart 2/30 24/8836 0.00293625751289305 0.0176175450773583 0.0109502535819169 FOS/JUN 2
GO B_10_10 GO:0034976 response to endoplasmic reticulum stress 4/41 277/18986 0.00293723741838456 0.0476485181204606 0.0350407270965175 DDIT3/JUN/PMAIP1/PPP1R15A 4
MeSH_gene2pubmed B_10_10 D042846 CDC2-CDC28 Kinases 4/41 380/26076 0.00293757742992434 0.0228167389795182 0.0141766128823695 DDIT3/GADD45B/JUN/KLF6 4
KEGG B_10_10 hsa04620 Toll-like receptor signaling pathway 3/23 109/8541 0.0029733354450676 0.0198744000801887 0.0125193071371267 FOS/JUN/NFKBIA 3
KEGG B_10_10 hsa04659 Th17 cell differentiation 3/23 109/8541 0.0029733354450676 0.0198744000801887 0.0125193071371267 FOS/JUN/NFKBIA 3
MeSH_gene2pubmed B_10_10 D002358 Cartilage, Articular 4/41 382/26076 0.00299340036002534 0.0231889800977161 0.0144078956365058 DUSP1/GADD45B/NR4A2/SLC2A3 4
MeSH_gene2pubmed B_10_10 D001335 Vehicle Emissions 2/41 52/26076 0.00304305298905887 0.0234414799014716 0.0145647801051377 AREG/CD83 2
MeSH_gene2pubmed B_10_10 D015926 Complement C3a 2/41 52/26076 0.00304305298905887 0.0234414799014716 0.0145647801051377 CD83/JUN 2
GO B_10_10 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 2/41 38/18986 0.00304493134491294 0.047907763520631 0.035231376201185 CD83/NFKBID 2
GO B_10_10 GO:0051385 response to mineralocorticoid 2/41 38/18986 0.00304493134491294 0.047907763520631 0.035231376201185 FOS/FOSB 2