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Selected Module: B_10_10


Module Info

Module_Name B_10_10
Cell_Type B
Name B_10_10: HALLMARK_TNFA_SIGNALING_VIA_NFKB
Meta_Module B_12
Gene_Number 41

Genes:

ALG13, AREG, BTG2, CCNL1, CD69, CD83, CHMP1B, COQ7, CSRNP1, CXCR4, DDIT3, DUSP1, DUSP2, EIF1, FOS, FOSB, GADD45B, IER2, IFRD1, JUN, JUNB, JUND, KLF6, LY9, MYADM, NFKBIA, NFKBID, NR4A1, NR4A2, PHACTR1, PMAIP1, PPP1R15A, RBM38, SBDS, SERTAD1, SLC2A3, TSC22D3, TUBA1A, YPEL5, ZFP36, ZNF331


UMAP Visualizations


UMAP for B_10_10

UMAP for B_10_10


Word Cloud

Enriched TF

Wordcloud for B_10_10
TF p.adjust Genes
PSMB5 4.90379990902434e-09 BTG2/CCNL1/DUSP1/EIF1/JUNB/PMAIP1/PPP1R15A/SLC2A3/TUBA1A/ZFP36
CREB 4.90379990902434e-09 AREG/CHMP1B/DUSP1/EIF1/FOSB/JUND/NR4A2/PPP1R15A/TSC22D3
CREB 4.90379990902434e-09 AREG/DUSP1/FOSB/JUN/JUND/NFKBID/NR4A2/PPP1R15A/TSC22D3
CREB 1.73096420202783e-08 DUSP1/EIF1/FOS/FOSB/GADD45B/NFKBID/NR4A2/PPP1R15A/TSC22D3
SRF 1.17134429958281e-07 DUSP2/FOS/FOSB/IER2/IFRD1/JUNB/KLF6/NR4A1
CREB 3.64129821560901e-07 DUSP1/EIF1/FOS/FOSB/NFKBID/NR4A2/PPP1R15A/TSC22D3
ATF 6.82227196758743e-07 AREG/CHMP1B/DUSP1/FOS/FOSB/JUND/PPP1R15A
SRF 1.34911861648055e-06 DUSP2/FOS/FOSB/IER2/JUNB/KLF6/NR4A1


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
MeSH_gene2pubmed B_10_10 D051200 Toll-Like Receptor 8 2/41 50/26076 0.00281685542699183 0.0222607439160855 0.0138311591877872 CD83/NFKBIA 2
MeSH_gene2pubmed B_10_10 D010741 D010741 4/41 376/26076 0.00282808497299042 0.0222607439160855 0.0138311591877872 CD69/FOS/PMAIP1/TUBA1A 4
MeSH_gene2pubmed B_10_10 D015842 Serine Proteinase Inhibitors 4/41 376/26076 0.00282808497299042 0.0222607439160855 0.0138311591877872 AREG/DDIT3/FOS/JUN 4
MeSH_gene2pubmed B_10_10 D053495 Osteopontin 4/41 376/26076 0.00282808497299042 0.0222607439160855 0.0138311591877872 IFRD1/JUN/NR4A1/NR4A2 4
reactome B_10_10 R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 3/24 134/11146 0.00285864160031907 0.0252173026885289 0.0175172398816544 FOS/JUN/NFKBIA 3
MeSH_gene2pubmed B_10_10 D005234 Fatty Liver 3/41 181/26076 0.00288848653218978 0.0226149238893579 0.0140512200990453 DDIT3/KLF6/PPP1R15A 3
MeSH_gene2pubmed B_10_10 D019947 Receptors, Interleukin-6 3/41 181/26076 0.00288848653218978 0.0226149238893579 0.0140512200990453 CD83/FOS/JUN 3
GO B_10_10 GO:0071676 negative regulation of mononuclear cell migration 2/41 37/18986 0.00288860951647036 0.0475196607779913 0.0349459653882849 CD69/DUSP1 2
MeSH_gene2pubmed B_10_10 D050779 Nuclear Factor 90 Proteins 2/41 51/26076 0.00292891921657619 0.0228167389795182 0.0141766128823695 DUSP1/ZFP36 2
MeSH_gene2pubmed B_10_10 D001169 Arthritis, Experimental 3/41 182/26076 0.00293371218519578 0.0228167389795182 0.0141766128823695 CXCR4/DUSP1/DUSP2 3