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Selected Module: B_10_10
Module Info
| Module_Name | B_10_10 |
| Cell_Type | B |
| Name | B_10_10: HALLMARK_TNFA_SIGNALING_VIA_NFKB |
| Meta_Module | B_12 |
| Gene_Number | 41 |
Genes:
ALG13, AREG, BTG2, CCNL1, CD69, CD83, CHMP1B, COQ7, CSRNP1, CXCR4, DDIT3, DUSP1, DUSP2, EIF1, FOS, FOSB, GADD45B, IER2, IFRD1, JUN, JUNB, JUND, KLF6, LY9, MYADM, NFKBIA, NFKBID, NR4A1, NR4A2, PHACTR1, PMAIP1, PPP1R15A, RBM38, SBDS, SERTAD1, SLC2A3, TSC22D3, TUBA1A, YPEL5, ZFP36, ZNF331
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| PSMB5 | 4.90379990902434e-09 | BTG2/CCNL1/DUSP1/EIF1/JUNB/PMAIP1/PPP1R15A/SLC2A3/TUBA1A/ZFP36 |
| CREB | 4.90379990902434e-09 | AREG/CHMP1B/DUSP1/EIF1/FOSB/JUND/NR4A2/PPP1R15A/TSC22D3 |
| CREB | 4.90379990902434e-09 | AREG/DUSP1/FOSB/JUN/JUND/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| CREB | 1.73096420202783e-08 | DUSP1/EIF1/FOS/FOSB/GADD45B/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| SRF | 1.17134429958281e-07 | DUSP2/FOS/FOSB/IER2/IFRD1/JUNB/KLF6/NR4A1 |
| CREB | 3.64129821560901e-07 | DUSP1/EIF1/FOS/FOSB/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| ATF | 6.82227196758743e-07 | AREG/CHMP1B/DUSP1/FOS/FOSB/JUND/PPP1R15A |
| SRF | 1.34911861648055e-06 | DUSP2/FOS/FOSB/IER2/JUNB/KLF6/NR4A1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| MeSH_gene2pubmed | B_10_10 | D048848 | MAP Kinase Kinase Kinase 5 | 3/41 | 174/26076 | 0.00258397945163646 | 0.0211324893314893 | 0.0131301462826154 | DDIT3/DUSP1/PMAIP1 | 3 |
| GO | B_10_10 | GO:0032633 | interleukin-4 production | 2/41 | 35/18986 | 0.00258771636213888 | 0.0447964690368988 | 0.0329433297892118 | CD83/DDIT3 | 2 |
| GO | B_10_10 | GO:0032673 | regulation of interleukin-4 production | 2/41 | 35/18986 | 0.00258771636213888 | 0.0447964690368988 | 0.0329433297892118 | CD83/DDIT3 | 2 |
| GO | B_10_10 | GO:0043369 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment | 2/41 | 35/18986 | 0.00258771636213888 | 0.0447964690368988 | 0.0329433297892118 | CD69/LY9 | 2 |
| GO | B_10_10 | GO:0043434 | response to peptide hormone | 5/41 | 446/18986 | 0.00261187136815342 | 0.0447964690368988 | 0.0329433297892118 | AREG/BTG2/FOS/NR4A1/NR4A2 | 5 |
| MeSH_gene2pubmed | B_10_10 | D022161 | Transport Vesicles | 4/41 | 368/26076 | 0.00261758232000895 | 0.021347838032073 | 0.0132639478379401 | CD83/CHMP1B/CXCR4/SLC2A3 | 4 |
| MeSH_gene2pubmed | B_10_10 | D011720 | D011720 | 4/41 | 369/26076 | 0.00264328420661595 | 0.0214977352648876 | 0.0133570827527787 | AREG/DDIT3/DUSP1/FOS | 4 |
| GO | B_10_10 | GO:0071774 | response to fibroblast growth factor | 3/41 | 128/18986 | 0.00264636674961132 | 0.0447964690368988 | 0.0329433297892118 | IER2/NR4A1/ZFP36 | 3 |
| MeSH_gene2pubmed | B_10_10 | D007003 | Hypoglycemia | 3/41 | 176/26076 | 0.00266883996783189 | 0.0216456191866144 | 0.0134489667468818 | DDIT3/SBDS/SLC2A3 | 3 |
| WikiPathways | B_10_10 | WP3612 | Photodynamic therapy induced NFE2L2 NRF2 survival signaling | 2/30 | 23/8836 | 0.00269724702632866 | 0.0166594669273241 | 0.0103547563859057 | FOS/JUN | 2 |