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Selected Module: B_10_10


Module Info

Module_Name B_10_10
Cell_Type B
Name B_10_10: HALLMARK_TNFA_SIGNALING_VIA_NFKB
Meta_Module B_12
Gene_Number 41

Genes:

ALG13, AREG, BTG2, CCNL1, CD69, CD83, CHMP1B, COQ7, CSRNP1, CXCR4, DDIT3, DUSP1, DUSP2, EIF1, FOS, FOSB, GADD45B, IER2, IFRD1, JUN, JUNB, JUND, KLF6, LY9, MYADM, NFKBIA, NFKBID, NR4A1, NR4A2, PHACTR1, PMAIP1, PPP1R15A, RBM38, SBDS, SERTAD1, SLC2A3, TSC22D3, TUBA1A, YPEL5, ZFP36, ZNF331


UMAP Visualizations


UMAP for B_10_10

UMAP for B_10_10


Word Cloud

Enriched TF

Wordcloud for B_10_10
TF p.adjust Genes
PSMB5 4.90379990902434e-09 BTG2/CCNL1/DUSP1/EIF1/JUNB/PMAIP1/PPP1R15A/SLC2A3/TUBA1A/ZFP36
CREB 4.90379990902434e-09 AREG/CHMP1B/DUSP1/EIF1/FOSB/JUND/NR4A2/PPP1R15A/TSC22D3
CREB 4.90379990902434e-09 AREG/DUSP1/FOSB/JUN/JUND/NFKBID/NR4A2/PPP1R15A/TSC22D3
CREB 1.73096420202783e-08 DUSP1/EIF1/FOS/FOSB/GADD45B/NFKBID/NR4A2/PPP1R15A/TSC22D3
SRF 1.17134429958281e-07 DUSP2/FOS/FOSB/IER2/IFRD1/JUNB/KLF6/NR4A1
CREB 3.64129821560901e-07 DUSP1/EIF1/FOS/FOSB/NFKBID/NR4A2/PPP1R15A/TSC22D3
ATF 6.82227196758743e-07 AREG/CHMP1B/DUSP1/FOS/FOSB/JUND/PPP1R15A
SRF 1.34911861648055e-06 DUSP2/FOS/FOSB/IER2/JUNB/KLF6/NR4A1


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
MeSH_gene2pubmed B_10_10 D044102 Receptor, Melanocortin, Type 1 2/41 42/26076 0.00199564473098697 0.0181302239873035 0.0112647634339585 NR4A1/NR4A2 2
MeSH_gene2pubmed B_10_10 D013749 D013749 3/41 159/26076 0.00200074678878962 0.0181302239873035 0.0112647634339585 AREG/JUN/PPP1R15A 3
WikiPathways B_10_10 WP69 T cell receptor signaling 3/30 75/8836 0.00202265481236203 0.0138088606337515 0.00858295097035182 FOS/JUN/NFKBIA 3
MeSH_gene2pubmed B_10_10 D051785 Smad Proteins 4/41 343/26076 0.00202964125413402 0.0183354668373461 0.0113922859705725 BTG2/CD83/GADD45B/JUN 4
GO B_10_10 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 2/41 31/18986 0.0020334046595714 0.0393866764747751 0.028964967558955 CD69/LY9 2
WikiPathways B_10_10 WP516 Hypertrophy model 2/30 20/8836 0.00203845085545856 0.0138088606337515 0.00858295097035182 IFRD1/JUND 2
GO B_10_10 GO:0045444 fat cell differentiation 4/41 251/18986 0.00205700964465863 0.0393866764747751 0.028964967558955 DDIT3/NR4A1/NR4A2/ZFP36 4
MeSH_gene2pubmed B_10_10 D003571 Cytochalasin B 3/41 161/26076 0.0020731842065128 0.0185575269217121 0.0115302574771716 CXCR4/JUN/SLC2A3 3
MeSH_gene2pubmed B_10_10 D003676 Deferoxamine 3/41 161/26076 0.0020731842065128 0.0185575269217121 0.0115302574771716 DDIT3/DUSP1/SLC2A3 3
MeSH_gene2pubmed B_10_10 D014680 Veins 3/41 161/26076 0.0020731842065128 0.0185575269217121 0.0115302574771716 DUSP1/NR4A1/NR4A2 3