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Selected Module: B_10_10


Module Info

Module_Name B_10_10
Cell_Type B
Name B_10_10: HALLMARK_TNFA_SIGNALING_VIA_NFKB
Meta_Module B_12
Gene_Number 41

Genes:

ALG13, AREG, BTG2, CCNL1, CD69, CD83, CHMP1B, COQ7, CSRNP1, CXCR4, DDIT3, DUSP1, DUSP2, EIF1, FOS, FOSB, GADD45B, IER2, IFRD1, JUN, JUNB, JUND, KLF6, LY9, MYADM, NFKBIA, NFKBID, NR4A1, NR4A2, PHACTR1, PMAIP1, PPP1R15A, RBM38, SBDS, SERTAD1, SLC2A3, TSC22D3, TUBA1A, YPEL5, ZFP36, ZNF331


UMAP Visualizations


UMAP for B_10_10

UMAP for B_10_10


Word Cloud

Enriched TF

Wordcloud for B_10_10
TF p.adjust Genes
PSMB5 4.90379990902434e-09 BTG2/CCNL1/DUSP1/EIF1/JUNB/PMAIP1/PPP1R15A/SLC2A3/TUBA1A/ZFP36
CREB 4.90379990902434e-09 AREG/CHMP1B/DUSP1/EIF1/FOSB/JUND/NR4A2/PPP1R15A/TSC22D3
CREB 4.90379990902434e-09 AREG/DUSP1/FOSB/JUN/JUND/NFKBID/NR4A2/PPP1R15A/TSC22D3
CREB 1.73096420202783e-08 DUSP1/EIF1/FOS/FOSB/GADD45B/NFKBID/NR4A2/PPP1R15A/TSC22D3
SRF 1.17134429958281e-07 DUSP2/FOS/FOSB/IER2/IFRD1/JUNB/KLF6/NR4A1
CREB 3.64129821560901e-07 DUSP1/EIF1/FOS/FOSB/NFKBID/NR4A2/PPP1R15A/TSC22D3
ATF 6.82227196758743e-07 AREG/CHMP1B/DUSP1/FOS/FOSB/JUND/PPP1R15A
SRF 1.34911861648055e-06 DUSP2/FOS/FOSB/IER2/JUNB/KLF6/NR4A1


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
MeSH_gene2pubmed B_10_10 D008466 Mechlorethamine 2/41 38/26076 0.00163592061005299 0.015851692775959 0.00984905477582711 DDIT3/DUSP1 2
WikiPathways B_10_10 WP2880 Glucocorticoid receptor pathway 3/30 70/8836 0.00165852775503541 0.0128996603169421 0.00801783398145775 GADD45B/JUN/TSC22D3 3
WikiPathways B_10_10 WP5130 Th17 cell differentiation pathway 3/30 70/8836 0.00165852775503541 0.0128996603169421 0.00801783398145775 FOS/JUN/NFKBIA 3
GO B_10_10 GO:0002295 T-helper cell lineage commitment 2/41 28/18986 0.00165974690154182 0.0340102522982604 0.0250111444442867 CD69/LY9 2
MeSH_gene2pubmed B_10_10 D005755 Gastrins 3/41 149/26076 0.0016623470179743 0.0160547725156992 0.00997523331769205 AREG/FOS/JUN 3
reactome B_10_10 R-HSA-166166 MyD88-independent TLR4 cascade 3/24 111/11146 0.00167053918082821 0.0187270485745579 0.0130087744199998 FOS/JUN/NFKBIA 3
reactome B_10_10 R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 3/24 111/11146 0.00167053918082821 0.0187270485745579 0.0130087744199998 FOS/JUN/NFKBIA 3
reactome B_10_10 R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 3/24 111/11146 0.00167053918082821 0.0187270485745579 0.0130087744199998 FOS/JUN/NFKBIA 3
KEGG B_10_10 hsa05167 Kaposi sarcoma-associated herpesvirus infection 4/23 196/8541 0.00169131416072836 0.0187962502368579 0.0118401576295168 FOS/JUN/NFKBIA/ZFP36 4
MeSH_gene2pubmed B_10_10 D016662 Virus Integration 4/41 327/26076 0.00170570947068935 0.0164195508391604 0.0102018792500591 CD83/FOS/JUN/NR4A1 4