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Selected Module: B_10_10


Module Info

Module_Name B_10_10
Cell_Type B
Name B_10_10: HALLMARK_TNFA_SIGNALING_VIA_NFKB
Meta_Module B_12
Gene_Number 41

Genes:

ALG13, AREG, BTG2, CCNL1, CD69, CD83, CHMP1B, COQ7, CSRNP1, CXCR4, DDIT3, DUSP1, DUSP2, EIF1, FOS, FOSB, GADD45B, IER2, IFRD1, JUN, JUNB, JUND, KLF6, LY9, MYADM, NFKBIA, NFKBID, NR4A1, NR4A2, PHACTR1, PMAIP1, PPP1R15A, RBM38, SBDS, SERTAD1, SLC2A3, TSC22D3, TUBA1A, YPEL5, ZFP36, ZNF331


UMAP Visualizations


UMAP for B_10_10

UMAP for B_10_10


Word Cloud

Enriched TF

Wordcloud for B_10_10
TF p.adjust Genes
PSMB5 4.90379990902434e-09 BTG2/CCNL1/DUSP1/EIF1/JUNB/PMAIP1/PPP1R15A/SLC2A3/TUBA1A/ZFP36
CREB 4.90379990902434e-09 AREG/CHMP1B/DUSP1/EIF1/FOSB/JUND/NR4A2/PPP1R15A/TSC22D3
CREB 4.90379990902434e-09 AREG/DUSP1/FOSB/JUN/JUND/NFKBID/NR4A2/PPP1R15A/TSC22D3
CREB 1.73096420202783e-08 DUSP1/EIF1/FOS/FOSB/GADD45B/NFKBID/NR4A2/PPP1R15A/TSC22D3
SRF 1.17134429958281e-07 DUSP2/FOS/FOSB/IER2/IFRD1/JUNB/KLF6/NR4A1
CREB 3.64129821560901e-07 DUSP1/EIF1/FOS/FOSB/NFKBID/NR4A2/PPP1R15A/TSC22D3
ATF 6.82227196758743e-07 AREG/CHMP1B/DUSP1/FOS/FOSB/JUND/PPP1R15A
SRF 1.34911861648055e-06 DUSP2/FOS/FOSB/IER2/JUNB/KLF6/NR4A1


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
GO B_10_10 GO:0072540 T-helper 17 cell lineage commitment 2/41 24/18986 0.00121851965352043 0.0279064893198405 0.0205224362698179 CD69/LY9 2
MeSH_gene2pubmed B_10_10 D011940 Receptor Aggregation 4/41 299/26076 0.00122852260357626 0.0129746128205032 0.0080614527527363 AREG/CD69/CXCR4/LY9 4
MeSH_gene2pubmed B_10_10 D055550 Protein Stability 2/41 33/26076 0.0012348104528658 0.012994277740552 0.00807367106137121 CD69/PPP1R15A 2
MeSH_gene2pubmed B_10_10 D035362 Transcription Factor TFIID 4/41 301/26076 0.00125904518270477 0.0132019880586471 0.00820272669784723 FOS/IFRD1/JUN/JUND 4
MeSH_gene2pubmed B_10_10 D002525 Cerebellar Cortex 3/41 136/26076 0.00127958949635595 0.0133696610722458 0.00830690615165709 BTG2/CXCR4/DDIT3 3
MeSH_gene2pubmed B_10_10 D050956 HSP40 Heat-Shock Proteins 4/41 303/26076 0.00129009606340121 0.0134316384473261 0.00834541425111723 DDIT3/JUN/JUND/PPP1R15A 4
WikiPathways B_10_10 WP4928 MAPK pathway in congenital thyroid cancer 2/30 16/8836 0.00129835117165825 0.0109061498419293 0.00677875980149992 FOS/JUN 2
MeSH_gene2pubmed B_10_10 D010442 Peptide Chain Initiation, Translational 4/41 304/26076 0.00130582116049916 0.0135473177640479 0.0084172887154363 DDIT3/EIF1/PPP1R15A/ZFP36 4
MeSH_gene2pubmed B_10_10 D048292 Mitogen-Activated Protein Kinase 13 2/41 34/26076 0.00131068176225383 0.0135498649787931 0.00841887136392098 DDIT3/DUSP1 2
GO B_10_10 GO:0035994 response to muscle stretch 2/41 25/18986 0.00132266921093463 0.0294088245490387 0.0216272538140011 FOS/NFKBIA 2