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Selected Module: B_10_10


Module Info

Module_Name B_10_10
Cell_Type B
Name B_10_10: HALLMARK_TNFA_SIGNALING_VIA_NFKB
Meta_Module B_12
Gene_Number 41

Genes:

ALG13, AREG, BTG2, CCNL1, CD69, CD83, CHMP1B, COQ7, CSRNP1, CXCR4, DDIT3, DUSP1, DUSP2, EIF1, FOS, FOSB, GADD45B, IER2, IFRD1, JUN, JUNB, JUND, KLF6, LY9, MYADM, NFKBIA, NFKBID, NR4A1, NR4A2, PHACTR1, PMAIP1, PPP1R15A, RBM38, SBDS, SERTAD1, SLC2A3, TSC22D3, TUBA1A, YPEL5, ZFP36, ZNF331


UMAP Visualizations


UMAP for B_10_10

UMAP for B_10_10


Word Cloud

Enriched TF

Wordcloud for B_10_10
TF p.adjust Genes
PSMB5 4.90379990902434e-09 BTG2/CCNL1/DUSP1/EIF1/JUNB/PMAIP1/PPP1R15A/SLC2A3/TUBA1A/ZFP36
CREB 4.90379990902434e-09 AREG/CHMP1B/DUSP1/EIF1/FOSB/JUND/NR4A2/PPP1R15A/TSC22D3
CREB 4.90379990902434e-09 AREG/DUSP1/FOSB/JUN/JUND/NFKBID/NR4A2/PPP1R15A/TSC22D3
CREB 1.73096420202783e-08 DUSP1/EIF1/FOS/FOSB/GADD45B/NFKBID/NR4A2/PPP1R15A/TSC22D3
SRF 1.17134429958281e-07 DUSP2/FOS/FOSB/IER2/IFRD1/JUNB/KLF6/NR4A1
CREB 3.64129821560901e-07 DUSP1/EIF1/FOS/FOSB/NFKBID/NR4A2/PPP1R15A/TSC22D3
ATF 6.82227196758743e-07 AREG/CHMP1B/DUSP1/FOS/FOSB/JUND/PPP1R15A
SRF 1.34911861648055e-06 DUSP2/FOS/FOSB/IER2/JUNB/KLF6/NR4A1


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
GO B_10_10 GO:0051591 response to cAMP 3/41 91/18986 0.00099523795352196 0.023248758594273 0.0170971404226089 AREG/FOS/FOSB 3
MeSH_gene2pubmed B_10_10 D020932 Nerve Growth Factor 5/41 492/26076 0.00100286809269896 0.0109866444782244 0.00682627810152117 AREG/BTG2/CD83/DUSP1/NFKBIA 5
WikiPathways B_10_10 WP2849 Hematopoietic stem cell differentiation 3/30 59/8836 0.00101004683279252 0.00922216673419253 0.00573207355909711 CXCR4/FOS/FOSB 3
MeSH_gene2pubmed B_10_10 D054562 Protein Tyrosine Phosphatase, Non-Receptor Type 1 4/41 284/26076 0.00101594391776317 0.0110885180020545 0.00688957468003744 CXCR4/DUSP1/DUSP2/SLC2A3 4
MeSH_gene2pubmed B_10_10 D005095 Exoribonucleases 4/41 287/26076 0.00105620466102088 0.0114852477213233 0.00713607281695587 DDIT3/FOS/JUN/ZFP36 4
MeSH_gene2pubmed B_10_10 D002599 Chalcone 2/41 31/26076 0.00108964094210687 0.0117617125221535 0.00730784734005882 DDIT3/PMAIP1 2
MeSH_gene2pubmed B_10_10 D019595 Severe Dengue 2/41 31/26076 0.00108964094210687 0.0117617125221535 0.00730784734005882 CD69/PPP1R15A 2
reactome B_10_10 R-HSA-112409 RAF-independent MAPK1/3 activation 2/24 23/11146 0.00109360691757483 0.0187270485745579 0.0130087744199998 DUSP1/DUSP2 2
MeSH_gene2pubmed B_10_10 D004965 Estrogen Antagonists 4/41 290/26076 0.00109757620950223 0.0118039697842438 0.00733410283812363 AREG/JUN/PMAIP1/TSC22D3 4
MeSH_gene2pubmed B_10_10 D007986 Luteinizing Hormone 4/41 291/26076 0.00111161645638019 0.0119113354596068 0.00740081182830149 AREG/JUND/NR4A1/NR4A2 4