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Selected Module: B_10_10
Module Info
| Module_Name | B_10_10 |
| Cell_Type | B |
| Name | B_10_10: HALLMARK_TNFA_SIGNALING_VIA_NFKB |
| Meta_Module | B_12 |
| Gene_Number | 41 |
Genes:
ALG13, AREG, BTG2, CCNL1, CD69, CD83, CHMP1B, COQ7, CSRNP1, CXCR4, DDIT3, DUSP1, DUSP2, EIF1, FOS, FOSB, GADD45B, IER2, IFRD1, JUN, JUNB, JUND, KLF6, LY9, MYADM, NFKBIA, NFKBID, NR4A1, NR4A2, PHACTR1, PMAIP1, PPP1R15A, RBM38, SBDS, SERTAD1, SLC2A3, TSC22D3, TUBA1A, YPEL5, ZFP36, ZNF331
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| PSMB5 | 4.90379990902434e-09 | BTG2/CCNL1/DUSP1/EIF1/JUNB/PMAIP1/PPP1R15A/SLC2A3/TUBA1A/ZFP36 |
| CREB | 4.90379990902434e-09 | AREG/CHMP1B/DUSP1/EIF1/FOSB/JUND/NR4A2/PPP1R15A/TSC22D3 |
| CREB | 4.90379990902434e-09 | AREG/DUSP1/FOSB/JUN/JUND/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| CREB | 1.73096420202783e-08 | DUSP1/EIF1/FOS/FOSB/GADD45B/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| SRF | 1.17134429958281e-07 | DUSP2/FOS/FOSB/IER2/IFRD1/JUNB/KLF6/NR4A1 |
| CREB | 3.64129821560901e-07 | DUSP1/EIF1/FOS/FOSB/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| ATF | 6.82227196758743e-07 | AREG/CHMP1B/DUSP1/FOS/FOSB/JUND/PPP1R15A |
| SRF | 1.34911861648055e-06 | DUSP2/FOS/FOSB/IER2/JUNB/KLF6/NR4A1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_10_10 | GO:0035914 | skeletal muscle cell differentiation | 3/41 | 80/18986 | 0.00068423756012237 | 0.0190283207195936 | 0.0139934298009989 | BTG2/FOS/NR4A1 | 3 |
| MeSH_gene2pubmed | B_10_10 | D030361 | Papillomavirus Infections | 4/41 | 257/26076 | 0.0007008318051133 | 0.00864555537736416 | 0.00537170065573358 | CD83/FOS/JUN/PPP1R15A | 4 |
| MeSH_gene2pubmed | B_10_10 | D050808 | ets-Domain Protein Elk-4 | 2/41 | 25/26076 | 0.00070720444459598 | 0.00868766631520417 | 0.00539786523886735 | FOS/JUN | 2 |
| MeSH_gene2pubmed | B_10_10 | D017320 | HIV Protease Inhibitors | 3/41 | 111/26076 | 0.00071129092334728 | 0.00869476244811369 | 0.00540227424443605 | CD83/DDIT3/SLC2A3 | 3 |
| MeSH_gene2pubmed | B_10_10 | D009336 | D009336 | 5/41 | 456/26076 | 0.0007137049557205 | 0.00869476244811369 | 0.00540227424443605 | CD69/CD83/DDIT3/DUSP1/PMAIP1 | 5 |
| GO | B_10_10 | GO:0001764 | neuron migration | 4/41 | 189/18986 | 0.00072233997726584 | 0.019620769615035 | 0.0144291168041353 | CXCR4/NR4A2/PHACTR1/TUBA1A | 4 |
| MeSH_gene2pubmed | B_10_10 | D054648 | Protein Phosphatase 2 | 5/41 | 461/26076 | 0.00074955931464229 | 0.0090938270569825 | 0.00565022310689469 | AREG/DDIT3/DUSP1/DUSP2/PPP1R15A | 5 |
| GO | B_10_10 | GO:0045580 | regulation of T cell differentiation | 4/41 | 191/18986 | 0.00075131951086281 | 0.0196894257658624 | 0.0144796065473537 | CD69/CD83/JUNB/NFKBID | 4 |
| GO | B_10_10 | GO:1902105 | regulation of leukocyte differentiation | 5/41 | 337/18986 | 0.00075858232830805 | 0.0196894257658624 | 0.0144796065473537 | CD69/CD83/FOS/JUNB/NFKBID | 5 |
| MeSH_gene2pubmed | B_10_10 | D003260 | Contact Inhibition | 3/41 | 114/26076 | 0.00076857858560562 | 0.00924814232515616 | 0.00574610305804375 | AREG/DUSP1/SERTAD1 | 3 |