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Selected Module: B_10_10


Module Info

Module_Name B_10_10
Cell_Type B
Name B_10_10: HALLMARK_TNFA_SIGNALING_VIA_NFKB
Meta_Module B_12
Gene_Number 41

Genes:

ALG13, AREG, BTG2, CCNL1, CD69, CD83, CHMP1B, COQ7, CSRNP1, CXCR4, DDIT3, DUSP1, DUSP2, EIF1, FOS, FOSB, GADD45B, IER2, IFRD1, JUN, JUNB, JUND, KLF6, LY9, MYADM, NFKBIA, NFKBID, NR4A1, NR4A2, PHACTR1, PMAIP1, PPP1R15A, RBM38, SBDS, SERTAD1, SLC2A3, TSC22D3, TUBA1A, YPEL5, ZFP36, ZNF331


UMAP Visualizations


UMAP for B_10_10

UMAP for B_10_10


Word Cloud

Enriched TF

Wordcloud for B_10_10
TF p.adjust Genes
PSMB5 4.90379990902434e-09 BTG2/CCNL1/DUSP1/EIF1/JUNB/PMAIP1/PPP1R15A/SLC2A3/TUBA1A/ZFP36
CREB 4.90379990902434e-09 AREG/CHMP1B/DUSP1/EIF1/FOSB/JUND/NR4A2/PPP1R15A/TSC22D3
CREB 4.90379990902434e-09 AREG/DUSP1/FOSB/JUN/JUND/NFKBID/NR4A2/PPP1R15A/TSC22D3
CREB 1.73096420202783e-08 DUSP1/EIF1/FOS/FOSB/GADD45B/NFKBID/NR4A2/PPP1R15A/TSC22D3
SRF 1.17134429958281e-07 DUSP2/FOS/FOSB/IER2/IFRD1/JUNB/KLF6/NR4A1
CREB 3.64129821560901e-07 DUSP1/EIF1/FOS/FOSB/NFKBID/NR4A2/PPP1R15A/TSC22D3
ATF 6.82227196758743e-07 AREG/CHMP1B/DUSP1/FOS/FOSB/JUND/PPP1R15A
SRF 1.34911861648055e-06 DUSP2/FOS/FOSB/IER2/JUNB/KLF6/NR4A1


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
WikiPathways B_10_10 WP2873 Aryl hydrocarbon receptor pathway 3/30 45/8836 0.00045522972525811 0.00637321615361363 0.00396129725838642 JUN/JUNB/JUND 3
reactome B_10_10 R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 2/24 15/11146 0.00045866778451483 0.0125878825305737 0.0087441928509845 DDIT3/PPP1R15A 2
MeSH_gene2pubmed B_10_10 D014568 Urokinase-Type Plasminogen Activator 5/41 415/26076 0.00046608619236035 0.00680810477995031 0.00423004645907568 AREG/FOS/FOSB/NFKBIA/SLC2A3 5
GO B_10_10 GO:0051412 response to corticosterone 2/41 15/18986 0.00046930753872535 0.0137037801307803 0.0100777618842076 FOS/FOSB 2
GO B_10_10 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 2/41 15/18986 0.00046930753872535 0.0137037801307803 0.0100777618842076 BTG2/ZFP36 2
MeSH_gene2pubmed B_10_10 D009061 Mouth Mucosa 5/41 416/26076 0.00047121403082142 0.00684893264599846 0.00425541383748578 CD83/DDIT3/FOS/JUN/SLC2A3 5
MeSH_gene2pubmed B_10_10 D053614 Janus Kinase 2 5/41 417/26076 0.00047638439011415 0.00688997324815355 0.00428091339418117 CXCR4/DDIT3/DUSP1/FOS/NFKBIA 5
MeSH_gene2pubmed B_10_10 D013472 Sunlight 3/41 97/26076 0.00048005635859094 0.0069090464157991 0.00429276403218838 DUSP1/NFKBIA/SLC2A3 3
MeSH_gene2pubmed B_10_10 D015689 Oncogene Protein p21(ras) 4/41 234/26076 0.00049321635479512 0.00701560974242652 0.00435897450294893 DDIT3/DUSP1/JUN/JUNB 4
MeSH_gene2pubmed B_10_10 D051997 ADP-ribosyl Cyclase 1 4/41 234/26076 0.00049321635479512 0.00701560974242652 0.00435897450294893 CD69/CD83/CXCR4/DUSP1 4