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Selected Module: B_10_10
Module Info
| Module_Name | B_10_10 |
| Cell_Type | B |
| Name | B_10_10: HALLMARK_TNFA_SIGNALING_VIA_NFKB |
| Meta_Module | B_12 |
| Gene_Number | 41 |
Genes:
ALG13, AREG, BTG2, CCNL1, CD69, CD83, CHMP1B, COQ7, CSRNP1, CXCR4, DDIT3, DUSP1, DUSP2, EIF1, FOS, FOSB, GADD45B, IER2, IFRD1, JUN, JUNB, JUND, KLF6, LY9, MYADM, NFKBIA, NFKBID, NR4A1, NR4A2, PHACTR1, PMAIP1, PPP1R15A, RBM38, SBDS, SERTAD1, SLC2A3, TSC22D3, TUBA1A, YPEL5, ZFP36, ZNF331
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| PSMB5 | 4.90379990902434e-09 | BTG2/CCNL1/DUSP1/EIF1/JUNB/PMAIP1/PPP1R15A/SLC2A3/TUBA1A/ZFP36 |
| CREB | 4.90379990902434e-09 | AREG/CHMP1B/DUSP1/EIF1/FOSB/JUND/NR4A2/PPP1R15A/TSC22D3 |
| CREB | 4.90379990902434e-09 | AREG/DUSP1/FOSB/JUN/JUND/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| CREB | 1.73096420202783e-08 | DUSP1/EIF1/FOS/FOSB/GADD45B/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| SRF | 1.17134429958281e-07 | DUSP2/FOS/FOSB/IER2/IFRD1/JUNB/KLF6/NR4A1 |
| CREB | 3.64129821560901e-07 | DUSP1/EIF1/FOS/FOSB/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| ATF | 6.82227196758743e-07 | AREG/CHMP1B/DUSP1/FOS/FOSB/JUND/PPP1R15A |
| SRF | 1.34911861648055e-06 | DUSP2/FOS/FOSB/IER2/JUNB/KLF6/NR4A1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| MeSH_gene2pubmed | B_10_10 | D054641 | Dual Specificity Phosphatase 2 | 2/41 | 19/26076 | 0.00040552218288004 | 0.00616897994267262 | 0.00383294214851988 | DUSP1/DUSP2 | 2 |
| hallmark | B_10_10 | HALLMARK_APOPTOSIS | HALLMARK_APOPTOSIS | 6/28 | 161/4384 | 0.00042994275232203 | 0.0026871422020127 | 0.00169714244337644 | BTG2/CD69/DDIT3/GADD45B/JUN/PMAIP1 | 6 |
| MeSH_gene2pubmed | B_10_10 | D011522 | Protons | 5/41 | 408/26076 | 0.0004313626129285 | 0.00649477246952864 | 0.00403536522647825 | DUSP1/DUSP2/NFKBIA/SLC2A3/ZNF331 | 5 |
| MeSH_gene2pubmed | B_10_10 | D023201 | CD40 Ligand | 5/41 | 408/26076 | 0.0004313626129285 | 0.00649477246952864 | 0.00403536522647825 | CD69/CD83/JUN/NFKBIA/PMAIP1 | 5 |
| MeSH_gene2pubmed | B_10_10 | D003840 | Deoxycholic Acid | 3/41 | 94/26076 | 0.00043786831183705 | 0.00655632084267892 | 0.00407360677626652 | AREG/DDIT3/PPP1R15A | 3 |
| MeSH_gene2pubmed | B_10_10 | D015254 | DNA Modification Methylases | 4/41 | 227/26076 | 0.00043991662329964 | 0.00655632084267892 | 0.00407360677626652 | CXCR4/DDIT3/GADD45B/PMAIP1 | 4 |
| MeSH_gene2pubmed | B_10_10 | D015759 | Ionomycin | 5/41 | 412/26076 | 0.00045095550011606 | 0.00663028583181993 | 0.00411956308136524 | CXCR4/DUSP1/FOS/PMAIP1/ZFP36 | 5 |
| MeSH_gene2pubmed | B_10_10 | D016282 | Aspartic Acid Endopeptidases | 5/41 | 412/26076 | 0.00045095550011606 | 0.00663028583181993 | 0.00411956308136524 | AREG/BTG2/CD69/CXCR4/PMAIP1 | 5 |
| MeSH_gene2pubmed | B_10_10 | D054418 | Chemokine CCL20 | 3/41 | 95/26076 | 0.00045165434821661 | 0.00663028583181993 | 0.00411956308136524 | AREG/CD83/CXCR4 | 3 |
| WikiPathways | B_10_10 | WP5353 | Macrophage stimulating protein MSP signaling | 4/30 | 108/8836 | 0.00045284113847923 | 0.00637321615361363 | 0.00396129725838642 | DUSP1/FOS/JUN/NR4A1 | 4 |