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Selected Module: B_10_10


Module Info

Module_Name B_10_10
Cell_Type B
Name B_10_10: HALLMARK_TNFA_SIGNALING_VIA_NFKB
Meta_Module B_12
Gene_Number 41

Genes:

ALG13, AREG, BTG2, CCNL1, CD69, CD83, CHMP1B, COQ7, CSRNP1, CXCR4, DDIT3, DUSP1, DUSP2, EIF1, FOS, FOSB, GADD45B, IER2, IFRD1, JUN, JUNB, JUND, KLF6, LY9, MYADM, NFKBIA, NFKBID, NR4A1, NR4A2, PHACTR1, PMAIP1, PPP1R15A, RBM38, SBDS, SERTAD1, SLC2A3, TSC22D3, TUBA1A, YPEL5, ZFP36, ZNF331


UMAP Visualizations


UMAP for B_10_10

UMAP for B_10_10


Word Cloud

Enriched TF

Wordcloud for B_10_10
TF p.adjust Genes
PSMB5 4.90379990902434e-09 BTG2/CCNL1/DUSP1/EIF1/JUNB/PMAIP1/PPP1R15A/SLC2A3/TUBA1A/ZFP36
CREB 4.90379990902434e-09 AREG/CHMP1B/DUSP1/EIF1/FOSB/JUND/NR4A2/PPP1R15A/TSC22D3
CREB 4.90379990902434e-09 AREG/DUSP1/FOSB/JUN/JUND/NFKBID/NR4A2/PPP1R15A/TSC22D3
CREB 1.73096420202783e-08 DUSP1/EIF1/FOS/FOSB/GADD45B/NFKBID/NR4A2/PPP1R15A/TSC22D3
SRF 1.17134429958281e-07 DUSP2/FOS/FOSB/IER2/IFRD1/JUNB/KLF6/NR4A1
CREB 3.64129821560901e-07 DUSP1/EIF1/FOS/FOSB/NFKBID/NR4A2/PPP1R15A/TSC22D3
ATF 6.82227196758743e-07 AREG/CHMP1B/DUSP1/FOS/FOSB/JUND/PPP1R15A
SRF 1.34911861648055e-06 DUSP2/FOS/FOSB/IER2/JUNB/KLF6/NR4A1


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
MeSH_gene2pubmed B_10_10 D051636 X-Linked Inhibitor of Apoptosis Protein 4/41 203/26076 0.00028818819619132 0.00485991436553907 0.00301958683331393 DDIT3/DUSP1/PMAIP1/SBDS 4
GO B_10_10 GO:0035259 nuclear glucocorticoid receptor binding 2/40 12/18737 0.00028934671213459 0.00612450540684885 0.00431481939148075 NR4A1/NR4A2 2
MeSH_gene2pubmed B_10_10 D006107 Granulosa Cells 5/41 374/26076 0.00028967473227838 0.00485991436553907 0.00301958683331393 AREG/JUN/JUND/NR4A1/NR4A2 5
MeSH_gene2pubmed B_10_10 D017304 Annexin A5 5/41 375/26076 0.00029325169359911 0.00489197143413074 0.00303950469501957 CD83/DDIT3/DUSP2/NR4A1/PMAIP1 5
GO B_10_10 GO:0038066 p38MAPK cascade 3/41 60/18986 0.00029364651002996 0.0100876212857353 0.00741843814812547 DUSP1/GADD45B/ZFP36 3
MeSH_gene2pubmed B_10_10 D017879 D017879 3/41 83/26076 0.00030375773154191 0.00503860282376879 0.00313061045948348 DDIT3/NFKBIA/PPP1R15A 3
MeSH_gene2pubmed B_10_10 D019005 Cystic Fibrosis Transmembrane Conductance Regulator 5/41 380/26076 0.00031164320918569 0.00514036214701798 0.00319383608231112 AREG/DDIT3/JUN/PPP1R15A/SBDS 5
MeSH_gene2pubmed B_10_10 D051702 Activating Transcription Factor 6 3/41 84/26076 0.00031466488157508 0.00515564304160802 0.00320333048584064 DDIT3/PMAIP1/PPP1R15A 3
MeSH_gene2pubmed B_10_10 D007529 Isoflavones 4/41 208/26076 0.00031608165786425 0.00515564304160802 0.00320333048584064 DDIT3/DUSP1/NFKBIA/PMAIP1 4
WikiPathways B_10_10 WP2526 PDGF pathway 3/30 40/8836 0.00032060949417519 0.00517907644436847 0.00321907508321649 FOS/JUN/NFKBIA 3