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Selected Module: B_10_10
Module Info
| Module_Name | B_10_10 |
| Cell_Type | B |
| Name | B_10_10: HALLMARK_TNFA_SIGNALING_VIA_NFKB |
| Meta_Module | B_12 |
| Gene_Number | 41 |
Genes:
ALG13, AREG, BTG2, CCNL1, CD69, CD83, CHMP1B, COQ7, CSRNP1, CXCR4, DDIT3, DUSP1, DUSP2, EIF1, FOS, FOSB, GADD45B, IER2, IFRD1, JUN, JUNB, JUND, KLF6, LY9, MYADM, NFKBIA, NFKBID, NR4A1, NR4A2, PHACTR1, PMAIP1, PPP1R15A, RBM38, SBDS, SERTAD1, SLC2A3, TSC22D3, TUBA1A, YPEL5, ZFP36, ZNF331
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| PSMB5 | 4.90379990902434e-09 | BTG2/CCNL1/DUSP1/EIF1/JUNB/PMAIP1/PPP1R15A/SLC2A3/TUBA1A/ZFP36 |
| CREB | 4.90379990902434e-09 | AREG/CHMP1B/DUSP1/EIF1/FOSB/JUND/NR4A2/PPP1R15A/TSC22D3 |
| CREB | 4.90379990902434e-09 | AREG/DUSP1/FOSB/JUN/JUND/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| CREB | 1.73096420202783e-08 | DUSP1/EIF1/FOS/FOSB/GADD45B/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| SRF | 1.17134429958281e-07 | DUSP2/FOS/FOSB/IER2/IFRD1/JUNB/KLF6/NR4A1 |
| CREB | 3.64129821560901e-07 | DUSP1/EIF1/FOS/FOSB/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| ATF | 6.82227196758743e-07 | AREG/CHMP1B/DUSP1/FOS/FOSB/JUND/PPP1R15A |
| SRF | 1.34911861648055e-06 | DUSP2/FOS/FOSB/IER2/JUNB/KLF6/NR4A1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_10_10 | GO:2000319 | regulation of T-helper 17 cell differentiation | 3/41 | 28/18986 | 2.94930121691881e-05 | 0.00206793827308799 | 0.00152076210421756 | CD69/JUNB/NFKBID | 3 |
| GO | B_10_10 | GO:0002294 | CD4-positive, alpha-beta T cell differentiation involved in immune response | 4/41 | 83/18986 | 3.03986631868526e-05 | 0.00206793827308799 | 0.00152076210421756 | CD69/JUNB/LY9/NFKBID | 4 |
| MeSH_gene2pubmed | B_10_10 | D013778 | Tetrazolium Salts | 6/41 | 389/26076 | 3.06693465148264e-05 | 0.00101174383559023 | 0.00062862185109632 | AREG/CXCR4/DDIT3/DUSP1/JUN/NFKBIA | 6 |
| GO | B_10_10 | GO:0002287 | alpha-beta T cell activation involved in immune response | 4/41 | 84/18986 | 3.18689117427944e-05 | 0.00206793827308799 | 0.00152076210421756 | CD69/JUNB/LY9/NFKBID | 4 |
| GO | B_10_10 | GO:0002293 | alpha-beta T cell differentiation involved in immune response | 4/41 | 84/18986 | 3.18689117427944e-05 | 0.00206793827308799 | 0.00152076210421756 | CD69/JUNB/LY9/NFKBID | 4 |
| GO | B_10_10 | GO:2000514 | regulation of CD4-positive, alpha-beta T cell activation | 4/41 | 84/18986 | 3.18689117427944e-05 | 0.00206793827308799 | 0.00152076210421756 | CD69/CD83/JUNB/NFKBID | 4 |
| MeSH_gene2pubmed | B_10_10 | D051940 | B7-2 Antigen | 5/41 | 236/26076 | 3.3436323521525e-05 | 0.00109076717621331 | 0.00067772103699184 | CD69/CD83/NFKBIA/TSC22D3/ZFP36 | 5 |
| WikiPathways | B_10_10 | WP2374 | Oncostatin M signaling | 4/30 | 56/8836 | 3.50817721341648e-05 | 0.00092089651852182 | 0.00057238680850479 | FOS/JUNB/JUND/NFKBIA | 4 |
| GO | B_10_10 | GO:1903706 | regulation of hemopoiesis | 7/41 | 433/18986 | 3.51577126281621e-05 | 0.00216127412366807 | 0.00158940130219281 | CD69/CD83/FOS/JUNB/NFKBIA/NFKBID/ZFP36 | 7 |
| MeSH_gene2pubmed | B_10_10 | D003035 | Cobalt | 5/41 | 239/26076 | 3.55125891980155e-05 | 0.00114576881192718 | 0.00071189493441481 | DDIT3/JUN/NR4A1/SLC2A3/ZFP36 | 5 |