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Selected Module: B_10_1
Module Info
| Module_Name | B_10_1 |
| Cell_Type | B |
| Name | B_10_1: RNA splicing |
| Meta_Module | B_6 |
| Gene_Number | 104 |
Genes:
ACIN1, ADAM17, ANKRD11, ANKRD12, AQR, ARAP2, ATAD2B, ATM, ATRX, BCLAF1, BIRC6, BRAF, CCNL2, CCNT2, CELF2, CENATAC, CEP350, CHD1, CYTH1, DDHD1, DDX3X, DENND4A, DIDO1, DNAJB14, EP300, EPB41, ERBIN, FAM133B, FUS, HELZ, IKBKB, IQGAP1, IREB2, KANSL1, KDM2A, KDM5A, KMT2C, LUC7L3, MAP3K1, MAP3K2, MECP2, MIDEAS, MIER1, NFAT5, NKTR, OSBPL8, PCM1, PHIP, PKN2, PPP4R3A, PRRC2C, PTBP3, PUM2, RAB11FIP1, RAB3GAP1, RAB3GAP2, RAB8B, RBM25, RBM39, RESF1, RLF, RLIM, RNF19A, ROCK1, RSF1, SAFB, SAFB2, SCAF8, SECISBP2, SERINC1, SF3B1, SFT2D2, SLC38A1, SMCHD1, SMG1, SNRNP200, SNX13, SON, SPAG9, SPG7, SREK1, SRSF11, STK17B, THOC1, TRA2A, TRIP12, TRPM7, UBA6, UBXN7, UPF2, USP22, USP47, USP9X, VPS13A, VPS4B, YTHDF3, ZBTB11, ZC3H13, ZFC3H1, ZNF148, ZNF207, ZNF292, ZNF638, ZZEF1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| E2F | 0.0290062664910923 | ERBIN/LUC7L3/PRRC2C/SLC38A1/SREK1 |
| TCANNTGAY | 0.0296270794821563 | ATRX/BRAF/KDM2A/PCM1/TRPM7/YTHDF3/ZNF207 |
| ZNF777 | 0.0296270794821563 | FAM133B/KDM5A/THOC1 |
| FOXO1 | 0.0296270794821563 | CHD1/LUC7L3/SPAG9/SREK1/YTHDF3 |
| SP1 | 0.0296270794821563 | ADAM17/ANKRD12/IQGAP1/NFAT5/UPF2 |
| ELF1 | 0.0296270794821563 | BRAF/IKBKB/IQGAP1/MIDEAS/RLIM |
| MEIS1 | 0.0296270794821563 | DENND4A/EPB41/RLIM/RSF1/SPAG9 |
| SP1 | 0.0296270794821563 | ANKRD12/KDM2A/NFAT5/SPAG9/UPF2 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_10_1 | GO:0008380 | RNA splicing | 20/102 | 484/18986 | 1.09700465542596e-12 | 2.11392797100583e-09 | 1.89262171604543e-09 | ACIN1/AQR/CCNL2/CELF2/CENATAC/FUS/LUC7L3/PTBP3/RBM25/RBM39/SF3B1/SNRNP200/SON/SREK1/SRSF11/THOC1/TRA2A/USP22/ZC3H13/ZNF638 | 20 |
| GO | B_10_1 | GO:0016607 | nuclear speck | 16/102 | 416/19960 | 3.51270323616563e-10 | 7.90358228137267e-08 | 6.80355153109975e-08 | ACIN1/BCLAF1/CCNL2/ERBIN/LUC7L3/PPP4R3A/RBM25/RBM39/SF3B1/SON/SREK1/SRSF11/THOC1/TRIP12/ZC3H13/ZNF638 | 16 |
| GO | B_10_1 | GO:0043484 | regulation of RNA splicing | 11/102 | 190/18986 | 6.08790719414476e-09 | 5.86569858155848e-06 | 5.25162099537014e-06 | ACIN1/CCNL2/CELF2/FUS/PTBP3/RBM25/RBM39/SON/TRA2A/USP22/ZNF638 | 11 |
| MeSH_gene2pubmed | B_10_1 | D020365 | RNA Helicases | 13/104 | 447/26076 | 2.75885046476468e-08 | 8.60485459960103e-05 | 7.88160016986457e-05 | AQR/ATM/DDX3X/EP300/HELZ/IKBKB/NFAT5/SAFB/SF3B1/SMG1/SNRNP200/SREK1/UPF2 | 13 |
| GO | B_10_1 | GO:1903311 | regulation of mRNA metabolic process | 14/102 | 406/18986 | 3.60082730360209e-08 | 2.31293140468041e-05 | 2.07079156161538e-05 | ACIN1/CELF2/FUS/IREB2/PUM2/RBM25/RBM39/ROCK1/SAFB/SAFB2/SECISBP2/SON/TRA2A/YTHDF3 | 14 |
| MeSH_gene2pubmed | B_10_1 | D017381 | Spliceosomes | 12/104 | 422/26076 | 1.24803068841696e-07 | 0.00013841505658652 | 0.00012678100726475 | AQR/CCNT2/CHD1/EP300/FUS/OSBPL8/RBM39/SECISBP2/SF3B1/SNRNP200/SREK1/SRSF11 | 12 |
| MeSH_gene2pubmed | B_10_1 | D034521 | Nuclear Matrix-Associated Proteins | 10/104 | 270/26076 | 1.33134071740804e-07 | 0.00013841505658652 | 0.00012678100726475 | DDX3X/EPB41/FUS/RBM25/SAFB/SAFB2/SNRNP200/SREK1/SRSF11/UPF2 | 10 |
| MeSH_gene2pubmed | B_10_1 | D034961 | Antigens, Nuclear | 12/104 | 472/26076 | 4.12861074659354e-07 | 0.00032192842296563 | 0.00029486972542775 | ACIN1/ATM/CHD1/EP300/EPB41/FUS/MECP2/NFAT5/RBM25/SAFB/THOC1/UPF2 | 12 |
| GO | B_10_1 | GO:0050684 | regulation of mRNA processing | 8/102 | 136/18986 | 7.01902236909357e-07 | 0.00033814140263108 | 0.0003027415174459 | ACIN1/CELF2/RBM25/RBM39/SAFB/SAFB2/SON/TRA2A | 8 |
| GO | B_10_1 | GO:0140993 | histone modifying activity | 13/102 | 438/18737 | 7.37777966898537e-07 | 0.00020879116463228 | 0.00017240706173839 | ATM/BRAF/EP300/IKBKB/KDM2A/KDM5A/KMT2C/MIER1/ROCK1/SMG1/STK17B/TRPM7/USP22 | 13 |